abstract：:Near-infrared chemical imaging (NIR-CI) with high-speed cameras based on the push-broom acquisition principle is a rapidly-evolving and can be used for a variety of purposes, from classification (and sorting) of products to mapping spatial distribution of materials. The present study examined if NIR-CI is suitable for...

journal_title：International journal of pharmaceutics

authors： Wahl PR,Pucher I,Scheibelhofer O,Kerschhaggl M,Sacher S,Khinast JG

更新日期：2017-02-25 00:00:00

abstract：:Mixing of raw materials (drug+polymer) in the investigated mini pharma melt extruder is achieved by using co-rotating conical twin screws and an internal recirculation channel. In-line Raman spectroscopy was implemented in the barrels, allowing monitoring of the melt during processing. The aim of this study was twofol...

journal_title：International journal of pharmaceutics

authors： Van Renterghem J,Kumar A,Vervaet C,Remon JP,Nopens I,Vander Heyden Y,De Beer T

更新日期：2017-01-30 00:00:00

abstract：:The primary purpose of the present study was to design and optimize a liposomal formulation of the poorly water-soluble drug oleanolic acid (OA) to improve its oral bioavailability, and prolong the duration of therapeutic drug level. Liposomes containing a soybean lecithin and cholesterol lipid bilayer, a protective h...

journal_title：International journal of pharmaceutics

authors： Liu Y,Luo X,Xu X,Gao N,Liu X

更新日期：2017-01-30 00:00:00

abstract：:The study investigated the effects of different combined top-down and bottom-up nanocrystallization technologies on particle size and solid state of avanafil nanoparticles. Combined antisolvent precipitation-ultrasonication (sonoprecipitation) technique was adopted to prepare 18 formulas according to 32.21 factorial d...

journal_title：International journal of pharmaceutics

authors： Soliman KA,Ibrahim HK,Ghorab MM

更新日期：2017-01-30 00:00:00

abstract：:Herein we investigate the efficiency of various biomimetic coatings for localized drug delivery, using vancomycin as key therapeutic drug, which is a widely used antibiotic for the treatment of strong infections caused by positive Gram bacteria. We evaluate classical hydroxyapatite and biomimetic hydroxyapatite-collag...

journal_title：International journal of pharmaceutics

authors： Ionita D,Bajenaru-Georgescu D,Totea G,Mazare A,Schmuki P,Demetrescu I

更新日期：2017-01-30 00:00:00

abstract：:The immunostimulation capacity of most vaccines is enhanced through antigen adsorption on aluminum hydroxide (AH) adjuvants. Varying the adsorption conditions, i.e. pH and ionic strength (I), changes the antigen adsorbed amount and therefore the ability of the vaccine to stimulate the immune system. Vaccine formulatio...

journal_title：International journal of pharmaceutics

authors： Art JF,Vander Straeten A,Dupont-Gillain CC

更新日期：2017-01-30 00:00:00

abstract：:The present study developed novel zinc ion cross-linked alginate/N-succinyl-chitosan (NSC) blend microspheres (MS) for co-delivery of zinc and 5-aminosalicylic acid (5-ASA) for synergistic therapy of colitis. Physicochemical characterization of blend MS was assessed using scanning electron microscopy (SEM), Fourier tr...

journal_title：International journal of pharmaceutics

authors： Duan H,Lü S,Qin H,Gao C,Bai X,Wei Y,Wu X,Liu M,Zhang X,Liu Z

更新日期：2017-01-10 00:00:00

abstract：:The aim of this study was to prepare spherical agglomerates of lactose and to evaluate their physicochemical properties, flow properties, particle friability and compaction properties, and to compare them to commercially available types of lactose for direct compression (spray-dried, granulated and anhydrous β-lactose...

journal_title：International journal of pharmaceutics

authors： Lamešić D,Planinšek O,Lavrič Z,Ilić I

更新日期：2017-01-10 00:00:00

abstract：:The present investigation aims to develop lumefantrine loaded binary solid lipid nanoparticles (LF-SLNs) to improve its poor and variable oral bioavailability. The oral bioavailability of LF is poor and variable due to its limited aqueous solubility and P-gp mediated efflux occurring in small intestine. LF-SLNs were p...

journal_title：International journal of pharmaceutics

authors： Garg A,Bhalala K,Tomar DS,Wahajuddin

更新日期：2017-01-10 00:00:00

abstract：:Non-viral delivery using cationic solid lipid nanoparticles (SLNs) represents a useful strategy to introduce large DNA and RNA molecules to target cells. A careful selection of components and their amounts is critical to improve transfection efficiency. In this work, a selected and optimized formulation of SLNs was us...

journal_title：International journal of pharmaceutics

authors： Fàbregas A,Prieto-Sánchez S,Suñé-Pou M,Boyero-Corral S,Ticó JR,García-Montoya E,Pérez-Lozano P,Miñarro M,Suñé-Negre JM,Hernández-Munain C,Suñé C

更新日期：2017-01-10 00:00:00

abstract：:The aim of the present work was the development of a powder formulation for the delivery of manuka honey (MH) bioactive components in the treatment of chronic skin ulcers. In particular pectin (PEC)/chitosan glutamate (CS)/hyaluronic acid (HA) mini-capsules were obtained by inverse ionotropic gelation in presence of c...

journal_title：International journal of pharmaceutics

authors： Tenci M,Rossi S,Bonferoni MC,Sandri G,Mentori I,Boselli C,Cornaglia AI,Daglia M,Marchese A,Caramella C,Ferrari F

更新日期：2017-01-10 00:00:00

abstract：:The vitamin E analogue, α-tocopherol succinate (α-TOS), has a broad anti-tumor effect. α-TOS can induce cancer cells apoptosis and suppress tumor growth by targeting mitochondria. Low bioavailability of α-TOS is the major problem encountered with formulation development. In our study, α-TOS nanoemulsion (α-TOS-NE) was...

journal_title：International journal of pharmaceutics

authors： Gao Y,Qi X,Zheng Y,Ji H,Wu L,Zheng N,Tang J

更新日期：2016-12-30 00:00:00

abstract：:Over the last 10 years, the development of intelligent biomaterials for medical and pharmaceutical applications has attracted growing interest by combining interdisciplinary efforts. Between them nanogels represent one of the most attractive carriers for innovative drug delivery systems. In the present investigation n...

journal_title：International journal of pharmaceutics

authors： Nita LE,Chiriac AP,Diaconu A,Tudorachi N,Mititelu-Tartau L

更新日期：2016-12-30 00:00:00

abstract：:The present study focuses on the development of dry powders for inhalation as adjuvant chemotherapy in lung cancer treatment. Cisplatin was chosen as a potential candidate for a local treatment as it remains the main platinum component used in conventional chemotherapies, despite its high and cumulative systemic toxic...

journal_title：International journal of pharmaceutics

authors： Levet V,Rosière R,Merlos R,Fusaro L,Berger G,Amighi K,Wauthoz N

更新日期：2016-12-30 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs. Debilitating diseases such as rheumatoid arthritis and osteoarthritis are commonly managed by NSAIDs. However, NSAIDs pharmacological mechanism is often associated with the presence of gastrointestinal side effects. NSAIDs encap...

journal_title：International journal of pharmaceutics

authors： Badri W,Miladi K,Nazari QA,Greige-Gerges H,Fessi H,Elaissari A

更新日期：2016-12-30 00:00:00

abstract：:Oral delivery is the most fascinating route for interminable drug remedy. However, the intestinal absorption of alendronate (ALN), a bisphosphonate drug after oral administration is very poor. Absorption enhancers, which help to achieve the efficiency-safety balance, are considered one of the most promising agents for...

journal_title：International journal of pharmaceutics

authors： Alama T,Katayama H,Hirai S,Ono S,Kajiyama A,Kusamori K,Katsumi H,Sakane T,Yamamoto A

更新日期：2016-12-30 00:00:00

abstract：:This study investigates drug-excipient interactions in amorphous solid dispersions (ASDs) of the model basic compound lumefantrine (LMN), with five acidic polymers. X-ray photoelectron spectroscopy (XPS) was used to measure the extent of the protonation of the tertiary amine in LMN by the five acidic polymers. The ext...

journal_title：International journal of pharmaceutics

authors： Song Y,Zemlyanov D,Chen X,Su Z,Nie H,Lubach JW,Smith D,Byrn S,Pinal R

更新日期：2016-12-05 00:00:00

abstract：:Topical formulations aim to target the skin for a variety of cosmetic, protective or therapeutic needs. Despite the use of creams and ointments over the millennia, the bioavailability of actives from topical preparations remains quite low, often not exceeding 1-2% of the applied dose. In this review we examine the rea...

journal_title：International journal of pharmaceutics

authors： Hadgraft J,Lane ME

更新日期：2016-11-30 00:00:00

abstract：:Despite the substantial body of research investigating the use of liposomes, niosomes and other bilayer vesicles for drug delivery, the translation of these systems into licensed products remains limited. Indeed, recent shortages in the supply of liposomal products demonstrate the need for new scalable production meth...

journal_title：International journal of pharmaceutics

authors： Joshi S,Hussain MT,Roces CB,Anderluzzi G,Kastner E,Salmaso S,Kirby DJ,Perrie Y

更新日期：2016-11-30 00:00:00

abstract：:One of the major problems in end-stage bronchotracheal cancer is stenosis of the upper airways, either due to luminal ingrowth of the tumor or mucus plugging. Airway stents that suppress tumor ingrowth and sustain mucociliary transport can alleviate these problems in end-stage bronchial cancer. We evaluated different ...

journal_title：International journal of pharmaceutics

authors： Chen W,Clauser J,Thiebes AL,McGrath DJ,McHugh PE,Steinseifer U,Jockenhoevel S,Hennink WE,Kok RJ

更新日期：2016-11-30 00:00:00

abstract：:In this work, the sizing of microemulsion droplets of a lipid-based pharmaceutical excipient (Labrasol® ALF) is performed by Taylor dispersion analysis (TDA) using fluorescent detection. An hydrophobic fluorescent marker is used to tag the microemulsion droplet and to increase the sensitivity of detection (compared to...

journal_title：International journal of pharmaceutics

authors： Chamieh J,Jannin V,Demarne F,Cottet H

更新日期：2016-11-20 00:00:00

abstract：:A novel, efficient delivery system for iron (Fe2+) was developed using the alginate biopolymer. Iron loaded alginate nanoparticles were synthesized by a controlled ionic gelation method and was characterized with respect to particle size, zeta potential, morphology and encapsulation efficiency. Successful loading was ...

journal_title：International journal of pharmaceutics

authors： Katuwavila NP,Perera AD,Dahanayake D,Karunaratne V,Amaratunga GA,Karunaratne DN

更新日期：2016-11-20 00:00:00

abstract：:This work focuses on the relevance of antibacterial nanofibers based on a polyelectrolyte complex formed between positively charged chitosan (CHT) and an anionic hydroxypropyl betacyclodextrin (CD)-citric acid polymer (PCD) complexing triclosan (TCL). The study of PCD/TCL inclusion complex and its release in dynamic c...

journal_title：International journal of pharmaceutics

authors： Ouerghemmi S,Degoutin S,Tabary N,Cazaux F,Maton M,Gaucher V,Janus L,Neut C,Chai F,Blanchemain N,Martel B

更新日期：2016-11-20 00:00:00

abstract：:The objective of this study was to prepare Herceptin (HCT)-functionalized paclitaxel nanocrystals and evaluated their cell-specific interactions, cellular accumulation, and growth inhibition in HER2-positve breast cancer cells as a tumor-targeted delivery module. Paclitaxel (PTX) was fabricated in the form of nanocrys...

journal_title：International journal of pharmaceutics

authors： Noh JK,Naeem M,Cao J,Lee EH,Kim MS,Jung Y,Yoo JW

更新日期：2016-11-20 00:00:00

abstract：:There are a range of products available which claim to accelerate the healing of burns; these include topical agents, interactive dressings and biomembranes. The aim of this study was to assess the effect of a gelatin-based membrane containing usnic acid/liposomes on the healing of burns in comparison to silver sulfad...

journal_title：International journal of pharmaceutics

authors： Nunes PS,Rabelo AS,Souza JC,Santana BV,da Silva TM,Serafini MR,Dos Passos Menezes P,Dos Santos Lima B,Cardoso JC,Alves JC,Frank LA,Guterres SS,Pohlmann AR,Pinheiro MS,de Albuquerque RL Júnior,Araújo AA

更新日期：2016-11-20 00:00:00

abstract：:An increasing elderly population is leading to a change in the global demographics. This presents a new challenge to society and the pharmaceutical industry. This demographic shift is providing an opportunity for the pharmaceutical industry to meet the specific needs of the changing patient population. One issue that ...

journal_title：International journal of pharmaceutics

authors： Page S,Coupe A,Barrett A

更新日期：2016-10-30 00:00:00

abstract：:The number of older people globally is increasing, contributing to a growing burden of morbidity and mortality. With this shift in population demographic, comes a new challenge in terms of appropriate healthcare for the over 65 years age group. As medication is the principal therapeutic intervention, it is essential t...

journal_title：International journal of pharmaceutics

authors： Quinn HL,Hughes CM,Donnelly RF

更新日期：2016-10-30 00:00:00

abstract：:A method for predicting dissolution profiles of directly compressed tablets for a fixed sustained release formulation manufactured in a continuous direct compaction (CDC) system is presented. The methodology enables real-time release testing (RTRt). Tablets were made at a target drug concentration of 9% Acetaminophen,...

journal_title：International journal of pharmaceutics

authors： Pawar P,Wang Y,Keyvan G,Callegari G,Cuitino A,Muzzio F

更新日期：2016-10-15 00:00:00

abstract：:Granules with release-sustaining properties were developed by twin screw hot melt granulation (HMG) using a combination of stearic acid (SA) and high molecular weight polyethylene oxide (PEO) as matrix for a highly water soluble model drug, metoprolol tartrate (MPT). Earlier studies demonstrated that mixing molten SA ...

journal_title：International journal of pharmaceutics

authors： Monteyne T,Adriaensens P,Brouckaert D,Remon JP,Vervaet C,De Beer T

更新日期：2016-10-15 00:00:00

abstract：:Phenotyping of cytochrome P450 isoenzymes is used for metabolic profiling. Phenotyping cocktails are usually administered as individual marketed products, which are not designed for diagnostic applications. Therefore, a formulation strategy was developed, which can be applied to any phenotyping cocktail. The formulati...

journal_title：International journal of pharmaceutics

authors： Camblin M,Berger B,Haschke M,Krähenbühl S,Huwyler J,Puchkov M

更新日期：2016-10-15 00:00:00

abstract：:The aim of this study was to develop a novel drug delivery system using two biocompatible copolymers of Solutol(®)HS15 and Soluplus(®) to improve solubility, oral bioavailability and anticancer activity of paclitaxel (PTX). The PTX-loaded mixed micelles (PTX-M) were prepared by ethanol thin-film hydration method. The ...

journal_title：International journal of pharmaceutics

authors： Hou J,Sun E,Sun C,Wang J,Yang L,Jia XB,Zhang ZH

更新日期：2016-10-15 00:00:00

abstract：:The phase transition of active pharmaceutical ingredients should be taken into account during manufacturing, processing- and storage, because different crystal forms lead to different physical properties of formulations. The phase transition of clarithromycin (CAM) metastable form I to stable form II was investigated ...

journal_title：International journal of pharmaceutics

authors： Watanabe M,Mizoguchi M,Aoki H,Iwao Y,Noguchi S,Itai S

更新日期：2016-10-15 00:00:00

abstract：:Drug solubility and lymphatic transport enhancements are two main pathways to improve drug oral bioavailability for microemulsions. However, it is not easy to have both achieved simultaneously because excipients used for improving lymphatic transport were usually insufficient in forming microemulsions and solubilizing...

journal_title：International journal of pharmaceutics

authors： Xing Q,Song J,You X,Xu D,Wang K,Song J,Guo Q,Li P,Wu C,Hu H

更新日期：2016-09-25 00:00:00

abstract：:Spray dried dispersions (SDDs) of glipizide, a BCS Class II model drug, were prepared using various grades of hydroxypropyl methylcellulose acetate succinate (HPMCAS) and copovidone S-630 as carriers. The SDDs appeared as a single amorphous phase with up to 60% drug loading level as revealed by X-ray powder diffractio...

journal_title：International journal of pharmaceutics

authors： Lu Z,Yang Y,Covington RA,Bi YV,Dürig T,Ilies MA,Fassihi R

更新日期：2016-09-25 00:00:00

abstract：:Active drug targeting and controlled release of hydrophilic macromolecular drugs represent crucial points in designing efficient polymeric drug delivery nanoplatforms. In the present work EGFR-targeted polylactide-co-glycolide (PLGA) nanoparticles were made by a blend of two different PLGA-based polymers. The first, G...

journal_title：International journal of pharmaceutics

authors： Colzani B,Speranza G,Dorati R,Conti B,Modena T,Bruni G,Zagato E,Vermeulen L,Dakwar GR,Braeckmans K,Genta I

更新日期：2016-09-25 00:00:00

abstract：:The feasibility of a colorimetric technique was investigated in CIELAB color space as an analytical quality control method for content uniformity of printed orodispersible pediatric delivery systems. Inkjet printing was utilized to fabricate orodispersibe film formulations containing propranolol hydrochloride in a col...

journal_title：International journal of pharmaceutics

authors： Vakili H,Nyman JO,Genina N,Preis M,Sandler N

更新日期：2016-09-10 00:00:00

abstract：:Chitosan/biomimetic apatite thin films were grown in mild conditions of temperature and pressure by Combinatorial Matrix-Assisted Pulsed Laser Evaporation on Ti, Si or glass substrates. Compositional gradients were obtained by simultaneous laser vaporization of the two distinct material targets. A KrF* excimer (λ=248n...

journal_title：International journal of pharmaceutics

authors： Visan A,Stan GE,Ristoscu C,Popescu-Pelin G,Sopronyi M,Besleaga C,Luculescu C,Chifiriuc MC,Hussien MD,Marsan O,Kergourlay E,Grossin D,Brouillet F,Mihailescu IN

更新日期：2016-09-10 00:00:00

abstract：:Recently, mesoporous silica nanoparticles (MSNs) have emerged as promising drug delivery systems able to preserve the integrity of the carried substance and/or to selectively reach a target site; however, they have rarely been explored for skin application. In this study, thermoresponsive MSNs, designed to work at phy...

journal_title：International journal of pharmaceutics

authors： Ugazio E,Gastaldi L,Brunella V,Scalarone D,Jadhav SA,Oliaro-Bosso S,Zonari D,Berlier G,Miletto I,Sapino S

更新日期：2016-09-10 00:00:00

abstract：:This research describes a rapid solubility classification approach that could be used in the discovery and development of new molecular entities. Compounds (N=635) were divided into two groups based on information available in the literature: high solubility (BDDCS/BCS 1/3) and low solubility (BDDCS/BCS 2/4). We estab...

journal_title：International journal of pharmaceutics

authors： Dave RA,Morris ME

更新日期：2016-09-10 00:00:00

abstract：:This paper first provides that Chinese yam polysaccharide (CYP) is encapsulated by PLGA using a double emulsion solvent evaporation method and aims to screen the optimal preparation of CYP-PLGA nanoparticles (CYPP) using response surface methodology (RSM). The volume ratio of the internal water phase to the organic ph...

journal_title：International journal of pharmaceutics

authors： Luo L,Zheng S,Huang Y,Qin T,Xing J,Niu Y,Bo R,Liu Z,Huang Y,Hu Y,Liu J,Wu Y,Wang D

更新日期：2016-09-10 00:00:00